THE THYROXINE-LIKE ACTIVITY OF SOME NEW THYROXINE ANALOGUES IN AMPHIBIA
نویسندگان
چکیده
منابع مشابه
The thyroxine-like activity of compounds structurally related to thyroxine.
In the course of a search for compounds which might prove to be competitive inhibitors of thyroxine in its action on the peripheral tissues, we have initiated a study of the relationship between chemical structure and thyroxine-like activity of a number of thyroxine analogues. Early attempts to relate chemical constitution to physiological activity have been summarized by Harington (1, 2) who c...
متن کاملStructural Analogues Antagonistic to Thyroxine
Since many compounds related structurally in specific ways to metabolically important substances have been found to produce signs of deficiency of the analogous metabolite, Woolley (1) proposed that’ new series of pharmacological agents might be produced by altering the structures of vitamins or hormones in definite ways. It was considered possible that such inhibitory structural analogues coul...
متن کاملStructural analogues antagonistic to thyroxine.
Since many compounds related structurally in specific ways to metabolically important substances have been found to produce signs of deficiency of the analogous metabolite, Woolley (1) proposed that’ new series of pharmacological agents might be produced by altering the structures of vitamins or hormones in definite ways. It was considered possible that such inhibitory structural analogues coul...
متن کاملTHE THYROXINE-LIKE ACTIVITY OF COMPOUNDS STRUCTURALLY RELATED TO THYROXINE* BY EARL FRIEDENt
In the course of a search for compounds which might prove to be competitive inhibitors of thyroxine in its action on the peripheral tissues, we have initiated a study of the relationship between chemical structure and thyroxine-like activity of a number of thyroxine analogues. Early attempts to relate chemical constitution to physiological activity have been summarized by Harington (1, 2) who c...
متن کاملSYNTHESIS AKD BIOLOGICAL ACTIVITY OF SOME TRIIODINATED ANALOGUES OF THYROXINE* BY KEXKICHI TOMITAt
Although it has been clearly established that thyroxine is the main circulating form of the thyroid hormone (1, 2), there is some evidence in favor of the view that it must be converted to some other substance before it is fully effective in peripheral tissues. Among these points of evidence are (a) t.he lag period between thyroxine administration and a detectable response in basal metabolic ra...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1954
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)65427-4